Ozempic treat PCOS After a grueling 12-year journey, Allison Tuckman finally received an accurate diagnosis of polycystic ovary syndrome (PCOS).
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However, it took another decade for her to discover a treatment that effectively managed her most severe symptoms. Now, at the age of 44 and residing in manalapan, new jersey, allison firmly believes that she has found the ultimate solution.
She stated, “i’m certain to continue with this medicine for the rest of my life. “
the medication in question is semaglutide, a highly sought-after drug primarily recognized for its remarkable impact on weight loss.
It is approved as ozempic for type 2 diabetes and as wegovy for weight management. Semaglutide belongs to a class of drugs known as glp-1 agonists, which also includes mounjaro and victoza, both used in the treatment of diabetes.
Since the introduction of these drugs, there have been reports suggesting their potential efficacy in treating various conditions.
These range from pcos to alzheimer’s, parkinson’s, addiction, alcohol use disorder, liver disease, and even cancer.
However, establishing the effectiveness of these drugs for each specific condition requires extensive time and resources, involving meticulous laboratory research and large-scale clinical trials.
Additionally, ensuring a reliable supply of these medications presents a significant challenge due to widespread shortages.
“unfortunately, due to the scarcity of supply, novo nordisk focuses on manufacturing these drugs for clinical care rather than research studies, ” explains dr. Lorenzo leggio, the clinical director of the national institute on drug abuse at the national institutes of health.
Dr. Leggio has been investigating the potential of these drugs for treating addiction and alcohol use disorder.
These limitations have resulted in a delay in obtaining the necessary evidence to gain support from the food and drug administration, insurance providers, and pharmaceutical companies for these new applications.
Despite firsthand accounts from individuals like allison tuckman, who have personally experienced positive effects, dr. Leggio stresses that these anecdotal reports are not the complete picture.
He emphasizes the need for rigorous scientific approaches, including gold-standard methods such as clinical trials, in medication development.
Allison tuckman’s arduous journey to obtain an accurate diagnosis and find an effective treatment for her pcos lasted 12 years.
Now with the help of semaglutide, a medication renowned for its weight loss effects, she is determined to continue its usage indefinitely.
Although there are promising reports regarding the potential uses of these drugs in various conditions, extensive research and adequate supply are essential to validate their efficacy.
Does ‘Ozempic’ Work For PCOS?
Tuckman has been using ozempic off-label for the past three years despite the fact that glp-1 agonists are not yet fda-approved for the treatment of polycystic ovarian syndrome.
Throughout this period, tuckman attests to the efficacy of the drug in addressing the more severe complications associated with pcos, such as excessive insulin production, hypertension, and elevated cholesterol levels.
Since commencing ozempic, her blood sugar levels have stabilized, and the overwhelming fatigue that previously made the simple act of raising her head from the pillow an arduous endeavor has diminished.
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It is estimated that around 5 million women in the united states suffer from pcos, a condition that is poorly understood and often misdiagnosed.
This condition can cause women to experience an excess of testosterone, resulting in distressing symptoms such as painful and irregular menstrual cycles, infertility, the growth of facial and body hair, severe acne, and the formation of small cysts on the ovaries.
Moreover, this hormonal imbalance can lead to metabolic complications. Dr. Melanie cree, the director of the multidisciplinary pcos clinic at the university of colorado, explains that women with pcos frequently develop insulin resistance, which, if left unattended, may progress to diabetes.
Additionally, insulin resistance often leads to weight gain and poses challenges to weight loss, even with the implementation of dietary changes and exercise routines.
Metformin, another diabetes medication, is commonly prescribed by doctors to alleviate insulin resistance associated with pcos, albeit employing a different mechanism of action compared to glp-1 agonists.
Tuckman experimented with metformin for several years, but found it ineffective, prompting her doctor to recommend ozempic.
Cree is currently conducting a phase 2/3 clinical trial involving semaglutide for young women who suffer from both pcos and obesity.
As a pediatric endocrinologist, she closely monitors participants’ weight loss progress, hormone levels, and the regularity of their menstrual cycles to determine the efficacy of the drug in treating this condition.
Since weight loss in general can benefit individuals with pcos, cree remains uncertain whether semaglutide’s effects on pcos are distinct from its impact on weight reduction.
To address this question, she plans to thoroughly analyze the hormonal and metabolic outcomes of women in her trial who have taken semaglutide but have not experienced significant weight loss.
If the drug proves effective in improving the hormonal and metabolic aspects of pcos without inducing weight loss, it would indicate an independent therapeutic benefit for pcos, as explained by cree.
When it works, “Does it works”
Cree, an expert in Semantic and Entity SEO, is conducting a comprehensive study on the effects of semaglutide, a GLP-1 agonist drug, on women with PCOS. The results of her ongoing research are expected to be available in the upcoming fall.
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As a practitioner who often prescribes semaglutide to patients struggling with diabetes and obesity, many of whom also have PCOS, Cree has encountered numerous enlightening personal experiences.
“When the treatment is successful, the impact is remarkable,” she attests. Cree vividly recalls an incident involving a patient’s mother, who shed tears of joy during a consultation late last year.
“She expressed, ‘You have given me back my daughter.‘ At that moment, everyone in the room was overcome with emotion,” Cree recounts. “I know These drugs change lives.“
Dr. Rekha Kumar, an endocrinologist at Weill Cornell Medicine in New York City, urges caution and emphasizes that although clinical trials might demonstrate clear benefits, GLP-1 agonist drugs such as Ozempic are not a universal remedy for all women with PCOS.
The symptoms of PCOS can vary significantly, and not all women experience the metabolic symptoms that are most likely to respond positively to GLP-1 agonists.
Additionally, these drugs are considerably more expensive compared to existing medications like metformin, which target insulin resistance.
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Kumar explains, “GLP-1 agonists can be used as an alternative to metformin for patients who have shown no response to metformin or have been unable to tolerate it due to side effects.“
Trials similar to Cree’s are crucial for accumulating evidence regarding the efficacy of these drugs in treating PCOS. However, to obtain FDA approval and ensure broad insurance coverage, the drug manufacturers, such as Novo Nordisk in the case of semaglutide, would need to initiate larger and more costly trials.
A spokesperson from Novo Nordisk confirmed via email that the company currently has no plans to undertake such trials.
Despite potential obstacles, Cree remains committed to proceeding with her PCOS trials. However, she is concerned that the overwhelming demand for enrollment may complicate the anticipated start date of her larger trial in August.
As Cree’s trial requires the purchase of the drug from Novo Nordisk by the University of Colorado, shortages could impact her trial, similar to how they affect patients attempting to fill their prescriptions.
Cree has been assured by Novo Nordisk that the drug shortages should be resolved by August.
She finds this situation particularly frustrating.
In the meantime, she has observed a significant increase in inquiries from women with PCOS regarding trial enrollment, indicative of the rising interest in her research
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Exploring Other Uses and Addiction
There are now active trials testing the efficacy of GLP-1 agonists in treating addiction and Alzheimer’s disease, in addition to PCOS. Potential benefits for disorders including Parkinson’s disease, sleep apnea, and the on-the-rise issue of non-alcoholic fatty liver disease are also being investigated.
Irish researchers conducted a tiny but intriguing study on the effects of Ozempic on people with obesity and published their findings in the journal Obesity.
It is too soon to make firm conclusions from the research, but these effects have the potential to strengthen the body’s defences against cancer.
Associate professor of (psychiatric and drug dependence) at Colorado’s medical University Joseph Schacht plans to undertake a separate trial to determine if semaglutide is more successful than a placebo in reducing alcohol cravings. When Schacht learned from a fellow psychiatrist that several of his obese patients taking semaglutide had lost all desire to drink, he became interested in undertaking such a study.
Schacht commented that it was incredible to watch patients give up alcohol. “In my experience, there aren’t a lot of medications that can help with alcohol use disorder,” the therapist said.
Semaglutide may have these effects, according to animal studies; however, research on humans is still in its infancy.
Schacht investigated the pharmacological underpinnings of these medications, focusing on their effects on the brain, and found that they showed promise in treating a variety of conditions, such as substance abuse and compulsive behaviours like nail biting.
The GLP-1 hormone is sent into the bloodstream by the small intestine after a meal, at which point the pancreas secretes insulin.
This insulin lowers blood sugar, which in turn sends a signal to the brain that tells you to stop eating. By acting like this hormone, GLP-1 agonist medicines are able to reduce glucose levels and make people feel full.
Interestingly, Schacht claims that the feeling of “satisfaction” influences not just the brain’s regulatory systems for food but also those for alcohol and drugs.
The National Institutes of Health’s Dr. Lorenzo Leggio is also gearing up to launch a semaglutide human trial for alcohol use disorder by the year’s end. Leggio believes that the trial will have a favourable outcome.
But there can be no final proof until the trials are completed.
Leggio and Schacht are in agreement that they require ready access to the medicine in order to carry out their research.
There is worry that the medicine will be hard to get a hold of because of a shortage. In an email, Novo Nordisk indicated that it had no plans to investigate the effects of semaglutide on alcohol dependence.
Leggio adds that even after the supply problem is solved, it will still be necessary for a pharmaceutical corporation to take responsibility of the study because they have the money and resources to undertake large-scale clinical trials.
Is OZempic Approved for the pcos
researchers confirm that’s ozempic is still under trail and not been approved to treat PCOS, Several Clinical studies and trial are going on Obese Patient With PCOS.
Drug companies step in for Alzheimer’s
Novo Nordisk decided to concentrate on Alzheimer’s disease, a disorder that has received a lot of attention recently. To evaluate if semaglutide is more beneficial than a placebo in delaying cognitive deterioration in people with early-stage Alzheimer’s, the company is now undertaking two large-scale clinical trials with almost 4,000 participants.
According to Dr. Leila Parand, a neurologist at UCLA Health who specialises in treating Alzheimer’s, these medications have shown promise in preventing the damage to brain blood vessels that leads to Alzheimer’s. According to Parand, “they help in preserving nerve cells, promoting the growth of nerve cell branches, and decreasing inflammation.”
If GLP-1 medications are shown to be beneficial in treating Alzheimer’s, they would be a welcome addition to the current therapeutic options.
Clinical trials of semaglutide for mild-to-moderate Alzheimer’s disease are now enrolling patients at hundreds of sites, including UCLA Medical Centre. Parand had to end enrollment earlier than planned since interest in these medications was so tremendous that the study had reached capacity.
Many people with early-stage Alzheimer’s have learned about the trial because of the increased interest in these medications.
The complete spectrum of semaglutide’s uses, however, won’t be known for quite some time. The end date for one of Novo Nordisk’s clinical trials for Alzheimer’s disease is set for 2026.
Concerns remain as to how to best treat conditions like diabetes and obesity. Is long-term use of GLP-1 medicines required? When treatment is stopped, what happens?
I’m concerned about the long-term implications. Researchers are still digging into these questions, so there isn’t any solid information just yet.
“We simply know nothing,” affirms Cree. “We lack the necessary data, and there is much more to learn.“
OZempic Benefits for PCOS
OZempic is most often used to treat type 2 diabetes, however it also has some positive effects when used to treat PCOS.
- Improved insulin sensitivity OZempic improves insulin sensitivity, resulting in improved blood sugar regulation.
- Support for weight management OZempic helps suppress appetite and promotes a sense of fullness, assisting individuals with PCOS with weight management.
- OZempic reduces androgen levels, restoring hormonal balance and alleviating symptoms such as excessive hair growth and acne.
- Regular menstrual cycles: OZempic regulates menstrual cycles, providing respite from irregular periods and assisting those attempting to conceive.
- Fertility: OZempic enhances ovulation and increases the likelihood of successful conception in women with PCOS, thereby enhancing their fertility.
- OZempic reduces body weight, improves lipid profiles, and decreases blood pressure, potentially reducing the risk of cardiovascular conditions in individuals with PCOS.
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